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Article

Coding, modifier, and regulatory effects shape circulating APOL1 levels.

Human molecular genetics - 11 Sept 2026

Adamson Walt E, Noyes Harry, Ogunsola John, Parekh Rulan S, Cooper Anneli, MacLeod Annette

Abstract excerpt

APOL1 variants G1 and G2 are major genetic risk factors for chronic kidney disease in people with recent sub-Saharan African ancestry, yet the mechanisms linking genotype to disease remain poorly defined. Circulating APOL1 is likely to play a critical role, although how specific genotypes and regulatory variants influence circulating APOL1 levels is incompletely understood. We analysed Olink-measured APOL1 NPX...

Read the complete abstract on PubMed

Topics

Female
Humans
Male
Apolipoprotein L1
Black People
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

MicroRNAs

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Renal Insufficiency, Chronic

Sub-Saharan African People

UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 42758720
DOI: 10.1093/hmg/ddag087
PMCID: PMC13626210

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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