Article
HLA class II and rheumatoid arthritis: the bumpy road of revelation.
Immunogenetics - 1 Aug 2017
Kampstra Arieke S B, Toes René E M
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic auto-immune disease primarily targeting the joints. Approximately 1% of the population is affected by RA, and despite the improvements in therapeutic interventions, elucidation of the disease pathogenesis is still in its infancy. RA patients can be subdivided on basis of the presence of autoantibodies, especially anti-citrullinated protein antibodies (ACPA). ACPA+ and ACPA-...
Topics
- Alleles
- Animals
- Antigen-Presenting Cells
- Arthritis, Rheumatoid
- Citrulline
- Epitopes
- HLA-DR Antigens
- Humans
- Mice