An overview on the genetic of rheumatoid arthritis: a never-ending story.

doi:10.1016/j.autrev.2011.04.021

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Article

An overview on the genetic of rheumatoid arthritis: a never-ending story.

Autoimmunity reviews - 1 Aug 2011

Perricone Carlo, Ceccarelli Fulvia, Valesini Guido

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, multi-factorial disease sustained by environmental and genetic factors. These seem to be necessary but not sufficient in the disease development, nonetheless they can be responsible of different clinical pictures and response to therapy, and they can represent potential therapeutic targets. Several genes have been indicated so far in the pathogenesis...

Topics

Animals
Arthritis, Rheumatoid
Cytokines
Genetic Markers
Genetic Predisposition to Disease
HLA Antigens
Humans
Hydrolases
Pathology, Molecular
Polymorphism, Genetic
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Protein-Arginine Deiminase Type 4
Protein-Arginine Deiminases
Receptors, IgG

Source

Open in PubMed

Identifiers

PMID: 21545847
DOI: 10.1016/j.autrev.2011.04.021

Genes

PADI4
PRF1
PTPN22
STAT4
TNF
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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