Article
Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Nov 2017
Scally Stephen W, Law Soi-Cheng, Ting Yi Tian, Heemst Jurgen van, Sokolove Jeremy, Deutsch Aaron J, Bridie Clemens E, Moustakas Antonis K, Papadopoulos George K, van der Woude Diane, Smolik Irene, Hitchon Carol A, Robinson David B, Ferucci Elizabeth D, Bernstein Charles N, Meng Xiaobo, Anaparti Vidyanand, Huizinga Tom, Kedzierska Katherine, Reid Hugh H, Raychaudhuri Soumya, Toes René E, Rossjohn Jamie, El-Gabalawy Hani, Thomas Ranjeny
Abstract excerpt
OBJECTIVE: The pathogenetic mechanisms by which HLA-DRB1 alleles are associated with anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) are incompletely understood. RA high-risk HLA-DRB1 alleles are known to share a common motif, the 'shared susceptibility epitope (SE)'. Here, the electropositive P4 pocket of HLA-DRB1 accommodates self-peptide residues containing citrulline but not...
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