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Article

Genetic risk of Alzheimer's disease is associated with loss of brain network segregation in midlife.

Communications biology - 19 May 2026

Deng Feng, Henson Richard N, Muniz-Terrera Graciela, Malhotra Paresh, O'Brien John T, Ritchie Craig W, Lawlor Brian, Naci Lorina

Abstract excerpt

Alzheimer's disease (AD) neuropathology starts decades before clinical manifestations, but the early indicators of AD in midlife remain unclear. Functional segregation of brain networks is a key marker of brain health. It remains unknown, however, whether inherited risk of AD impacts network segregation from midlife in individuals who are cognitively healthy but carry inherited risk for late-life AD. To address...

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Identifiers

PMID: 42157001
DOI: 10.1038/s42003-026-10282-0
PMCID: PMC13454165

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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