Article

Genetic risk of late-onset Alzheimer’s disease is associated with longitudinal loss of functional brain network segregation in middle-aged cognitively healthy individuals: The PREVENT-Dementia Study

2023-04-20

Abstract excerpt

It is well acknowledged that the pathological processes of Alzheimer’s disease (AD) start decades before clinical manifestations, but early indicators of AD in midlife remain unclear. Functional segregation of brain networks has recently emerged as a key indicator of brain health. In this study, we investigated the vulnerability of intrinsic brain networks to loss of functional segregation during healthy adult lif...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7dba5294-dcb4-5b8a-ad76-f993dd18a801
DOI: 10.1101/2023.04.18.23288690

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic risk of late-onset Alzheimer’s disease is associated with longitudinal loss of functional brain network segregation in middle-aged cognitively healthy individuals: The PREVENT-Dementia StudyDOI 10.1101/2023.04.18.23288690Read

Genetic risk of Alzheimer's disease is associated with loss of brain network segregation in midlife.Semantic proximity Read

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal dominant Alzheimer’s diseaseSemantic proximity Read

Executive dysfunction relates to salience network desegregation in behavioral variant frontotemporal dementiaSemantic proximity Read

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementiaSemantic proximity Read

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.Semantic proximity Read

Dementia risk factors modify hubs but leave other connectivity measures unchanged in asymptomatic individuals: a graph theoretical analysisSemantic proximity Read

Genetic variants link lower segregation of brain networks to higher blood pressure and worse cognition within the general aging populationSemantic proximity Read

Heterogeneous ageing of brain networks across the Alzheimer’s disease continuumSemantic proximity Read

Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageingSemantic proximity Read

Functional brain network controllability dysfunction in Alzheimer’s disease and its relationship with cognition and gene expression profilingSemantic proximity Read

Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele.Semantic proximity Read

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.Semantic proximity Read