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Article

Integration of Multilocus Genetic Risk into the Default Mode Network Longitudinal Trajectory during the Alzheimer's Disease Process.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Su Fan, Shu Hao, Ye Qing, Xie Chunming, Yuan Baoyu, Zhang Zhijun, Bai Feng

Abstract excerpt

The aim of the study was to investigate the cognitive significance of the changes in default mode network (DMN) during the process of Alzheimer's disease (AD) and the genetic basis that drives the alteration. Eighty-seven subjects with mild cognitive impairment (MCI) and 131 healthy controls (HC) were employed at baseline, and they had the genetic risk scores (GRS) based on the GWAS-validated AD-related top loci....

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PMID: 28035927
DOI: 10.3233/JAD-160787

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