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Article

Integrated genomic analyses identify oncogenic pathway interplay in hepatocarcinogenesis defining specific molecular subtypes.

Nature communications - 19 May 2026

Pan Long, Hirsch Théo Z, Fang Jing, Seretny Agnieszka, Imbeaud Sandrine, Jin Shuoshuo, Gege Olatunji Oluwole, Rebouissou Sandra, Sidali Sabrina, Ammiche Naïma, Calderaro Julien, Amaddeo Giuliana, Blanc Jean-Frédéric, Le Bail Brigitte, Ziol Marianne, Celton-Morizur Séverine, Paradis Valérie, Llovet Josep M, Tschaharganeh Darjus Felix, Nault Jean-Charles, Desdouets Chantal, Caruso Stefano, Zucman-Rossi Jessica

Abstract excerpt

Hepatocellular carcinoma (HCC) is a genomically diverse disease, and molecular classification is essential for understanding its biology and improving patient care. Here, integrative analyses of 529 HCC samples across genomic, transcriptomic, epigenomic, and proteomic layers identify nine robust molecular subtypes, validated in 807 external cases. Three common subtypes are defined by alterations in CTNNB1ex3/APC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carcinoma, Hepatocellular

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Source

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Identifiers

PMID: 42156413
DOI: 10.1038/s41467-026-73212-y
PMCID: PMC13381854

Genes

TP53
AXIN1
BAP1
APC
CCNA2
CTNNB1
HNF1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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