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Article

Advances in molecular classification and precision oncology in hepatocellular carcinoma.

Journal of hepatology - 1 Feb 2020

Rebouissou Sandra, Nault Jean-Charles

Abstract excerpt

Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential accumulation of multiple genomic and epigenomic alterations resulting from Darwinian selection. Genes from various signalling pathways such as telomere maintenance, Wnt/β-catenin, P53/cell cycle regulation, oxidative stress, epigenetic modifiers, AKT/mTOR and MAP kinase are frequently mutated in HCC. Several subclasses of HCC have been...

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Identifiers

PMID: 31954487
DOI: 10.1016/j.jhep.2019.08.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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