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Integrated exome sequencing and microarray analyses detected genetic defects and underlying pathways of hepatocellular carcinoma.

Cancer genetics - 1 Aug 2023

Chong Mei Ling, Knight James, Peng Gang, Ji Weizhen, Chai Hongyan, Lu Yufei, Wu Shengming, Li Peining, Hu Qiping

Abstract excerpt

We performed whole exome sequencing (WES) and microarray analysis to detect somatic variants and copy number alterations (CNAs) for underlying mechanisms in a case series of hepatocellular carcinoma (HCC) with paired DNA samples from tumor and adjacent nontumor tissues. Clinicopathologic findings based on Edmondson-Steiner (E-S) grading, Barcelona-Clinic Liver Cancer (BCLC) stages, recurrence, and survival status...

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Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37418972
DOI: 10.1016/j.cancergen.2023.06.002

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