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Article

The changing landscape of hepatocellular carcinoma: etiology, genetics, and therapy.

The American journal of pathology - 1 Mar 2014

Knudsen Erik S, Gopal Purva, Singal Amit G

Abstract excerpt

Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer death and has proved to be highly refractory to treatment. Extensive analysis of the disease has demonstrated that it arises predominantly in response to high-risk etiological challenges, most notably hepatitis virus. However, with evolving vaccination and the obesity epidemic, progressively more cases are associated with underlying...

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Identifiers

PMID: 24388934
DOI: 10.1016/j.ajpath.2013.10.028
PMCID: PMC3936328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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