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Article

Association of pyrazinamide resistance in Mycobacterium tuberculosis with mutations in rpoB, katG, and inhA genes.

Scientific reports - 18 May 2026

Srivastava Kartiki, Khan Salman, Prasad Rajniti, Pandey Sada Nand, Anupurba Shampa

Abstract excerpt

Multidrug-resistant tuberculosis (MDR-TB) is associated with a high rate of treatment failure. Since the 9 to 11-month shorter oral regimen in MDR-TB treatment includes pyrazinamide (PZA), it is essential to assess the susceptibility of MDR-TB strains to PZA to guide effective therapy. The susceptibility of PZA is highly affected by drug pressure induced by rifampicin (RIF) and isoniazid (INH) resistant strains....

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Identifiers

PMID: 42151375
DOI: 10.1038/s41598-026-53296-8
PMCID: PMC13381933

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