Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.

doi:10.4269/ajtmh.24-0042

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Article

Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.

The American journal of tropical medicine and hygiene - 3 Jul 2024

Suresh Parasmal, Thulasidharan Swathy, Kumar Anil, Sunil Sunisha, Roy Maria, Ramesh Varsha P, Biswas Raja, Kunoor Akhilesh, Biswas Lalitha

Abstract excerpt

The rising prevalence of drug-resistant Mycobacterium tuberculosis (MTB) strains poses a significant challenge to global tuberculosis (TB) control efforts. This study aimed to analyze drug resistance patterns and investigate the molecular characteristics of 193 MTB clinical isolates to shed light on the mechanisms of drug resistance. Of the 193 MTB clinical isolates, 28.5% (n = 53) exhibited mono-drug or...

Topics

Mycobacterium tuberculosis
India
Humans
Antitubercular Agents
Mutation
Tertiary Care Centers
Microbial Sensitivity Tests
Tuberculosis, Multidrug-Resistant
Bacterial Proteins
Isoniazid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rifampin

Pyrazinamide

Drug Resistance, Multiple, Bacterial

Adult

Female

Male

Ethambutol

Drug Resistance, Bacterial

Source

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Identifiers

PMID: 38772358
DOI: 10.4269/ajtmh.24-0042
PMCID: PMC11229631

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