Article
Association between overexpression of efflux pumps genes Rv0191 and Rv3008 and pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis: a multi-center study.
BMC infectious diseases - 6 Feb 2026
Hashemzadeh Mohammad, Hamid Sadegh, Khosravi Azar Dokht, Soleimanpour Saman, Savari Mohammad
Abstract excerpt
BACKGROUND: Pyrazinamide is a drug that helps shorten the duration of tuberculosis treatment. Mutations in the pncA are the most common mechanism of pyrazinamide resistance in M. tuberculosis. This study aimed to investigate the association between overexpression of Efflux pump genes Rv0191 and Rv3008 and pyrazinamide resistance in multidrug-resistant M. tuberculosis in a multicenter setting. METHODS: In this...
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