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Article

Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update.

Current microbiology - 8 Oct 2022

Rajendran Ananthi, Palaniyandi Kannan

Abstract excerpt

Pyrazinamide (PZA) has remained a keystone of tuberculosis (TB) therapy, and it possesses high imperative sterilizing action that can facilitate reduction in the present chemotherapy regimen. The combination of PZA works both with first- and second-line TB drugs, notably fluoroquinolones, clofazimine, bedaquiline, delamanid and pretomanid. Pyrazinamide inhibits various targets that are involved in different...

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PMID: 36209317
DOI: 10.1007/s00284-022-03032-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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