Article
Pyrazinamide resistance among multidrug-resistant tuberculosis clinical isolates in a national referral center of China and its correlations with pncA, rpsA, and panD gene mutations.
Diagnostic microbiology and infectious disease - 1 Mar 2016
Gu Yunting, Yu Xia, Jiang Guanglu, Wang Xiaobo, Ma Yifeng, Li Yunxu, Huang Hairong
Abstract excerpt
Our study was aimed to identify the phenotypic and genotypic pyrazinamide (PZA) resistance features among multidrug-resistant (MDR) isolates in a national tuberculosis (TB) referral center of China. PZA susceptibility test was performed for a total of 142 MDR-TB clinical isolates using the MGIT 960 PZA kits, and the pncA, rpsA, and panD genes were sequenced. Extensively drug-resistant (XDR) and pre-XDR strains...
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