Article
Phenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis clinical isolates in Hangzhou, China.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Sept 2018
Liu W, Chen J, Shen Y, Jin J, Wu J, Sun F, Wu Y, Xie L, Zhang Y, Zhang W
Abstract excerpt
OBJECTIVES: Pyrazinamide (PZA) is a crucial first-line tuberculosis (TB) drug recommended for both drug-susceptible and multidrug-resistant Mycobacterium tuberculosis. This study aimed to evaluate the performance of the sequencing method of pncA, rpsA and panD mutations in detecting PZA resistance in multidrug-resistant (MDR) TB isolates. METHODS: We sequenced the pncA, rpsA and panD genes and performed PZA...
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