Prevalence and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates from Southern China.

Abstract excerpt

BACKGROUND: Pyrazinamide (PZA) plays a unique role in the treatment for multidrug-resistant tuberculosis (MDR-TB) in both first- and second-line regimens. The aim of this study was to investigate the prevalence and molecular characterization of PZA resistance among MDR-TB isolates collected in Chongqing municipality. METHODS: A total of 133 MDR-TB isolates were collected from the smear-positive tuberculosis...

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• Amidohydrolases
• Antitubercular Agents
• Drug Resistance, Multiple, Bacterial
• Mycobacterium tuberculosis
• Prevalence