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Influence of iron uptake systems on cefiderocol activity in <i>Escherichia coli</i> : at the crossroads of antibiotic resistance and virulence

2025-11-08

Abstract excerpt

Cefiderocol (FDC) is a new siderophore-conjugated cephalosporin that enters the periplasm via iron transport systems. However, the specific contribution of individual iron uptake pathways to FDC activity remains unclear. We investigated the role of 12 iron acquisition systems using several Escherichia coli strain collections. FDC MICs were determined in iron-depleted and iron-supplemented media for E. coli muta...

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Literature Corpus work
745694a8-d4b2-5538-b60e-dc80e0ef15f1
DOI
10.1101/2025.11.06.687119
Open publication

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Influence of iron uptake systems on cefiderocol activity in <i>Escherichia coli</i> : at the crossroads of antibiotic resistance and virulenceDOI 10.1101/2025.11.06.687119
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