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Article

Evolution of antibiotic resistance and virulence in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae under last-resort antibiotic pressure.

Journal of global antimicrobial resistance - 1 May 2026

Ding Qi, Jin Longyang, Wang Ruobing, Wang Qi, Wang Hui

Abstract excerpt

OBJECTIVES: Carbapenem-resistant Klebsiella pneumoniae (CRKP), particularly the ST11-KL64 clone carrying blaKPC-2, is a critical global health threat. This study investigates the adaptive evolution of CRKP under last-line antibiotic pressure, focusing on resistance mechanisms, genetic alterations, and associated phenotypic changes. METHODS: A serial passage laboratory evolution model was established using a...

Topics

Klebsiella pneumoniae
Anti-Bacterial Agents
Virulence
Microbial Sensitivity Tests
Klebsiella Infections
Ceftazidime
Drug Resistance, Multiple, Bacterial
Tigecycline
Carbapenem-Resistant Enterobacteriaceae
Carbapenems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Colistin

Evolution, Molecular

Humans

Mutation

Drug Combinations

Whole Genome Sequencing

beta-Lactamases

Animals

Source

Identifiers

PMID: 41724355
DOI: 10.1016/j.jgar.2026.02.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41724355-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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