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Article

Influence of a putative TonB-dependent receptor on cefiderocol susceptibility in clinical Enterobacter hormaechei isolates.

The Journal of antimicrobial chemotherapy - 5 May 2026

Turowski Pia, Cremanns Martina, Pfennigwerth Niels, Gatermann Sören G

Abstract excerpt

OBJECTIVE: To investigate the emergence of resistance to cefiderocol (FDC) in clinical Enterobacter hormaechei isolates and to elucidate the underlying genetic mechanisms, with particular focus on mutations in a putative TonB-dependent receptor (TBDR). METHODS: Five non-duplicate clinical FDC-susceptible E. hormaechei isolates were exposed to stepwise increasing concentrations of FDC using disk diffusion and...

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Identifiers

PMID: 42219902
DOI: 10.1093/jac/dkag193

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