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Article

Identification of key amino acids defining conformational neutralizing epitopes of coxsackievirus A5 using monoclonal antibody escape mutants.

Frontiers in immunology - 1 Jan 2026

Xu Ke, Pei Jie, Wang Chen, Guo Jing, Chen Xiao-Qi, Shen Shuo

Abstract excerpt

Background: Coxsackievirus A5 (CVA5) is an emerging pathogen associated with severe hand, foot, and mouth disease. Protective antibodies are critical for protection from CVA5 infection, yet the antigenic determinants of CVA5 remain poorly defined. In this study, we aimed to map the conformational neutralizing epitopes of CVA5 using monoclonal antibodies (mAbs) and escape mutant analysis. Methods: Two IgG, one...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42136679
DOI: 10.3389/fimmu.2026.1837533
PMCID: PMC13167979

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