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Article

Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.

Journal of virology - 16 Apr 2020

Huang Liping, Sun Zhenzhao, Xia Deli, Wei Yanwu, Sun Encheng, Liu Chunguo, Zhu Hongzhen, Bian Haiqiao, Wu Hongli, Feng Li, Wang Jingfei, Liu Changming

Abstract excerpt

Porcine circovirus type 2 (PCV2) is an important pathogen in swine herds, and its infection of pigs has caused severe economic losses to the pig industry worldwide. The capsid protein of PCV2 is the only structural protein that is associated with PCV2 infection and immunity. Here, we report a neutralizing monoclonal antibody (MAb), MAb 3A5, that binds to intact PCV2 virions of the PCV2a, PCV2b, and PCV2d...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32075932
DOI: 10.1128/JVI.01836-19
PMCID: PMC7163150

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