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Article

Deep mutationally scanned CHIKV E3/E2 virus library maps viral amino acid preferences and predicts viral escape mutants of neutralizing CHIKV antibodies.

Journal of virology - 15 Apr 2025

Stumpf Megan M, Brunetti Tonya, Davenport Bennett J, McCarthy Mary K, Morrison Thomas E

Abstract excerpt

As outbreaks of chikungunya virus (CHIKV), a mosquito-borne alphavirus, continue to present public health challenges, additional research is needed to generate protective and safe vaccines and effective therapeutics. Prior research established a role for antibodies in mediating protection against CHIKV infection, and the early appearance of CHIKV-specific IgG or IgG neutralizing antibodies protects against...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40145739
DOI: 10.1128/jvi.00081-25
PMCID: PMC11998513

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