Article
Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity.
Vaccine - 2 Jan 2013
Chen Yixin, Li Chuan, He Delei, Cheng Tong, Ge Shengxiang, Shih James Wai-Kuo, Zhao Qinjian, Chen Pei-Jer, Zhang Jun, Xia Ningshao
Abstract excerpt
In recent year, Enterovirus 71 (EV71)-associated hand, foot and mouth disease (HFMD) has become an important public health issue in China. EV71 has been classified into genotypes A, B1-B5 and C1-C5. With such genetic diversity, whether the convalescent or recovery antibody responses can cross-protect infections from other genotypes remains a question. Understanding of the antigenicity of such diverse genetic EV71...
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