Article
Antigenic sites of coxsackie A9 virus inducing neutralizing monoclonal antibodies protective in mice.
Virology - 20 Jul 2003
Buttinelli Gabriele, Donati Valentina, Ruggeri Franco M, Joki-Korpela Paivi, Hyypia Timo, Fiore Lucia
Abstract excerpt
A panel of murine IgG monoclonal antibodies (MAbs) was produced against coxsackievirus A9 (CAV9). Fifty-nine MAbs reactive in ELISA with purified CAV9 were identified. Eighteen of them could efficiently inhibit infection by CAV9 but not coxsackieviruses B. Neutralization-resistant CAV9 variants to four different MAbs were isolated and tested for resistance to neutralization by other MAbs of the panel. Three...
Topics
- Animals
- Animals, Newborn
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigens, Viral
- Enterovirus B, Human
- Enterovirus Infections
- Enzyme-Linked Immunosorbent Assay
- Female
- Hybridomas
- Immunoglobulin G
- Mice
- Mice, Inbred BALB C
- Models, Molecular
- Mutation
- Neutralization Tests
- Protein Conformation