Article
Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody.
PLoS pathogens - 1 Mar 2016
Ye Xiaohua, Fan Chen, Ku Zhiqiang, Zuo Teng, Kong Liangliang, Zhang Chao, Shi Jinping, Liu Qingwei, Chen Tan, Zhang Yingyi, Jiang Wen, Zhang Linqi, Huang Zhong, Cong Yao
Abstract excerpt
Enterovirus 71 (EV71) is the main pathogen responsible for hand, foot and mouth disease with severe neurological complications and even death in young children. We have recently identified a highly potent anti-EV71 neutralizing monoclonal antibody, termed D5. Here we investigated the structural basis for recognition of EV71 by the antibody D5. Four three-dimensional structures of EV71 particles in complex with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.