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Article

Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia.

Molecular psychiatry - 1 Sept 2026

Kielhold Michelle L, Jacobs David S, Torrado Pacheco Alejandro, Lefner Merridee J, Bogachuk Alina P, Lebowitz Joseph J, Langdon Angela J, Williams John T, Zweifel Larry S, Moghaddam Bita

Abstract excerpt

Adolescence is associated with the emergence of several psychiatric disorders including schizophrenia. Recent studies have identified both common and rare variants of the GRIN2A gene as risk factors for schizophrenia. GRIN2A encodes the GluN2A subunit of the NMDA receptor and is developmentally regulated with low cortical expression at birth that reaches adult levels in adolescence. While global knockouts of...

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PMID: 42129480
DOI: 10.1038/s41380-026-03632-1

Genes

GRIN2A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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