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Article

Schizophrenia-like phenotypes and long-term synaptic plasticity impairment in GluN2A-transgenic mice.

Pharmacology, biochemistry, and behavior - 1 Jul 2025

Zhang Huan, Si Wen, Wang Bo, Han Jiao, Ding Fan, Xue Qingsheng, Cao Xiaohua

Abstract excerpt

While N-methyl-d-aspartate receptor (NMDAR) hypofunction has been suggested as a hallmark of schizophrenia, the role of subunit-specific dysregulation such as GluN2A overexpression remains poorly understood. The present study comprehensively investigated the impact of GluN2A overexpression on behavioral phenotypes, cognitive functions, and synaptic plasticity in transgenic mice with forebrain-specific...

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Identifiers

PMID: 40306373
DOI: 10.1016/j.pbb.2025.174026

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TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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