Article
ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2026
Yang Xijie, Qiao Xi, Schmidt Sarah, Eklund Ella A, Ebner-Walter Carolina, Ivarsson Emil, Crespo Michelle Ann, Kersemakers Nadieh, Dzanan Jozefina J, Thorisson Bjarni, Lundgren Christine, Lim Hooi Ching, Shkoukani Sam, Tüksammel Elin, Xu Xiufeng, Sayin Volkan I, Martín-Fontecha Mar, Ortega-Gutiérrez Silvia, Dalin Martin, Bergo Martin O
Abstract excerpt
Isoprenylcysteine carboxyl methyltransferase (ICMT) catalyzes C-terminal methylation of prenylated CAAX proteins, a final processing step promoting membrane association and signaling. Although ICMT has been pursued to disrupt RAS membrane targeting, its role in BRAFV600E-driven cancers and critical substrates remains unclear. Here, genetic and pharmacologic (UCM-1336) ICMT inhibition suppressed proliferation and...
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