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Article

Prenylated C17orf37 Induces Filopodia Formation to Promote Cell Migration and Metastasis

1 Jun 2011

Abstract excerpt

Post-translational modification by covalent attachment of isoprenoid lipids (prenylation) regulates the functions and biological activities of several proteins implicated in the oncogenic transformation and metastatic progression of cancer. The largest group of prenylated proteins contains a CAAX motif at the C-terminal that serves as a substrate for a series of post-translational modifications that convert these...

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PMID: 21628459
DOI: 10.1074/jbc.m111.254599

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