Article
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 2016
Lissanu Deribe Yonathan, Shi Yanxia, Rai Kunal, Nezi Luigi, Amin Samir B, Wu Chia-Chin, Akdemir Kadir C, Mahdavi Mozhdeh, Peng Qian, Chang Qing Edward, Hornigold Kirsti, Arold Stefan T, Welch Heidi C E, Garraway Levi A, Chin Lynda
Abstract excerpt
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on chromosome 10) binding protein that is significantly mutated in cutaneous melanoma and pancreatic ductal adenocarcinoma. Here, genetic and biochemical analyses were conducted to elucidate the nature and mechanistic basis of PREX2 mutation in melanoma development. By generating an...
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