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Article

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.

The Journal of clinical investigation - 1 Feb 2004

Bergo Martin O, Gavino Bryant J, Hong Christine, Beigneux Anne P, McMahon Martin, Casey Patrick J, Young Stephen G

Abstract excerpt

Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a kno...

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Identifiers

PMID: 14966563
DOI: 10.1172/JCI18829
PMCID: PMC338259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14966563-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.PMID 14966563Read ↗

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