Article
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2005
Winter-Vann Ann M, Baron Rudi A, Wong Waihay, dela Cruz June, York John D, Gooden David M, Bergo Martin O, Young Stephen G, Toone Eric J, Casey Patrick J
Abstract excerpt
Many key regulatory proteins, including members of the Ras family of GTPases, are modified at their C terminus by a process termed prenylation. This processing is initiated by the addition of an isoprenoid lipid, and the proteins are further modified by a proteolytic event and methylation of the C-terminal prenylcysteine. Although the biological consequences of prenylation have been characterized extensively, the...
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