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Article

Beyond chromatin accessibility: bulk ATAC-seq as an integrative assay to portray genomes and epigenomes.

NAR genomics and bioinformatics - 1 Jun 2026

Toumi Islem, Kham Chaimae, Stuani Lucille, Le Cam Laurent, Roux Pierre-François

Abstract excerpt

Assay for transposase-accessible chromatin using sequencing (ATAC-seq) is a cornerstone for epigenomic profiling, yet its potential for genomic characterization remains poorly explored. Here, we systematically benchmarked bulk ATAC-seq against whole-genome sequencing (WGS) to assess its capacity for detecting small variants, copy number variations (CNVs), telomere-associated repeat content, and mitochondrial...

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Identifiers

PMID: 42125447
DOI: 10.1093/nargab/lqag046
PMCID: PMC13158667

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