Article

Controlling for DNA dosage with Whole Genome Sequencing improves ATAC-seq peak calling

2026-04-26

Abstract excerpt

The Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is a scalable and sensitive method for profiling chromatin accessibility, enabling the identification of cis -regulatory elements (CREs) that govern gene expression in diverse cellular contexts. Although ATAC-seq is routinely applied to both bulk and single-cell samples, we reveal that its peak calling process is compromised by local biase...

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Literature Corpus work: 4c091393-0f8b-5626-a9f7-5b89387a4654
DOI: 10.64898/2026.04.23.720296

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