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Article

Cumulative Incidence in Monogenic Alzheimer's Disease and Frontotemporal Dementia: Gene-Gene Interaction Effect.

International journal of molecular sciences - 2 May 2026

Geviti Andrea, Pagano Lorenzo, Grassi Mario, Saraceno Claudia, Facconi Alessandro, Fostinelli Silvia, Laganà Valentina, Giacomucci Giulia, Cotelli Maria Sofia, Cantoni Valentina, Ingannato Assunta, Bagnoli Silvia, Bessi Valentina, Longobardi Antonio, Russotto Alice, Bellini Sonia, Lagrotteria Davide, Paparazzo Ersilia, Binetti Giuliano, Montesanto Alberto, Nacmias Benedetta, Maletta Raffaele, Borroni Barbara, Ghidoni Roberta

Abstract excerpt

Monogenic forms of Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD) represent the two principal neurodegenerative disorders leading to early-onset dementia, primarily linked to mutations in key AD- and FTD-associated genes. The marked heterogeneity in age at onset and penetrance among carriers of pathogenic mutations suggests that monogenic variants act within a broader polygenic background. The...

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Identifiers

PMID: 42123659
DOI: 10.3390/ijms27094081
PMCID: PMC13164024

Genes

APP
GRN
MAPT
PSEN1
PSEN2

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