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Article

Towards cascading genetic risk in Alzheimer's disease.

Brain : a journal of neurology - 1 Aug 2024

Altmann Andre, Aksman Leon M, Oxtoby Neil P, Young Alexandra L, Alexander Daniel C, Barkhof Frederik, Shoai Maryam, Hardy John, Schott Jonathan M

Abstract excerpt

Alzheimer's disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: amyloid (A), tau (T) and neurodegeneration (N). This progression of biomarkers has been condensed into the ATN framework, in which each of the biomarkers can be either positive (+) or negative (-). Over the past decades, genome-wide association studies have implicated ∼90 different loci...

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Identifiers

PMID: 38820112
DOI: 10.1093/brain/awae176
PMCID: PMC11292901

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