Article
Mutational Landscape of Alzheimer's Disease and Frontotemporal Dementia: Regional Variances in Northern, Central, and Southern Italy.
International journal of molecular sciences - 27 Jun 2024
Saraceno Claudia, Pagano Lorenzo, Laganà Valentina, Geviti Andrea, Bagnoli Silvia, Ingannato Assunta, Mazzeo Salvatore, Longobardi Antonio, Fostinelli Silvia, Bellini Sonia, Montesanto Alberto, Binetti Giuliano, Maletta Raffaele, Nacmias Benedetta, Ghidoni Roberta
Abstract excerpt
Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD) are the two major neurodegenerative diseases with distinct clinical and neuropathological profiles. The aim of this report is to conduct a population-based investigation in well-characterized APP, PSEN1, PSEN2, MAPT, GRN, and C9orf72 mutation carriers/pedigrees from the north, the center, and the south of Italy. We retrospectively analyzed the data of 467...
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