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Article

The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study.

Neurobiology of aging - 1 Sept 2022

Foote Isabelle F, Jacobs Benjamin M, Mathlin Georgina, Watson Cameron J, Bothongo Phazha Lk, Waters Sheena, Dobson Ruth, Noyce Alastair J, Bhui Kamaldeep S, Korszun Ania, Marshall Charles R

Abstract excerpt

Targeting modifiable risk factors may help to prevent Alzheimer's disease (AD), but the pathways by which these risk factors influence AD risk remain incompletely understood. We identified genome-wide association studies for AD and its major modifiable risk factors. We calculated the genetic correlation among these traits and modelled this using genomic structural equation modelling. We identified complex...

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PMID: 35797766
DOI: 10.1016/j.neurobiolaging.2022.02.016

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