Article
Multidimensional dissection of shared genetic susceptibility in ulcerative colitis and colorectal cancer: novel insights from integrative single-cell and multi-omics analysis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 11 May 2026
Zhu Fanfan, Yao Xin, Liu Da, Wang Shanshan, Huang Xuyu, Zhou Jing, Wang Song, Tang Shanneng, Lai Dongping, Yang Shuang, Meng Xiaobing, Zhang Xinyue, Zhu Ziming, Lu Xin, Zhang Tao, Xu Ri'an
Abstract excerpt
BACKGROUND: Ulcerative colitis (UC) patients carry a 2.5-fold increased risk of colorectal cancer (CRC), yet the shared multi-scale genetic architecture remains poorly understood. We constructed an integrative framework across tissue, cellular, and variant levels to systematically dissect the pathogenic evolution of this comorbidity across spatiotemporal dimensions. METHODS: We integrated GWAS data from 100,204...
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