Article
Transcriptome-Wide Association Study for Inflammatory Bowel Disease Reveals Novel Candidate Susceptibility Genes in Specific Colon Subsites and Tissue Categories.
Journal of Crohn's & colitis - 23 Feb 2022
Díez-Obrero Virginia, Moratalla-Navarro Ferran, Ibáñez-Sanz Gemma, Guardiola Jordi, Rodríguez-Moranta Francisco, Obón-Santacana Mireia, Díez-Villanueva Anna, Dampier Christopher Heaton, Devall Matthew, Carreras-Torres Robert, Casey Graham, Moreno Victor
Abstract excerpt
BACKGROUND AND AIMS: Genome-wide association studies [GWAS] for inflammatory bowel disease [IBD] have identified 240 risk variants. However, the benefit of understanding the genetic architecture of IBD remains to be exploited. Transcriptome-wide association studies [TWAS] associate gene expression with genetic susceptibility to disease, providing functional insight into risk loci. In this study, we integrate...
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