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Article

Integrated multi-omics analysis reveals common genetic architecture between ulcerative colitis and psoriasis.

Human immunology - 1 Oct 2026

Liu Guo, Wu Na, Luo Qinghua, Hu Siyao

Abstract excerpt

BACKGROUND: Ulcerative colitis (UC) and psoriasis (PS) are both chronic inflammatory disorders that frequently occur together in clinical settings. Nevertheless, the common genetic basis and biological mechanisms underlying this comorbidity remain insufficiently understood. METHODS: We integrated genome-wide association study summary data with UC and PS single-cell transcriptomic data and performed...

Read the complete abstract on PubMed

Topics

Colitis, Ulcerative
Psoriasis
Humans
Animals
Genome-Wide Association Study
Multiomics
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Gene Expression Profiling

Polymorphism, Single Nucleotide

Transcriptome

Genomics

Source

Identifiers

PMID: 42579900
DOI: 10.1016/j.humimm.2026.112041

Genes

PARK7
PUS10
TNFSF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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