Article

Integrative Bioinformatics of Bulk and Single-Cell Transcriptomes Identifies Predictive Molecular Features of Ulcerative Colitis-Associated Colorectal Cancer

2026-01-14

Abstract excerpt

<title>Abstract</title> <p>Ulcerative colitis (UC) is a chronic inflammatory disease that increases the risk of colorectal cancer (CRC), yet the molecular features linking these conditions remain unclear. Here, we integrated bulk RNA sequencing with single-cell transcriptomic data to investigate shared transcriptional programs between UC and CRC. UC-associated differentially expressed genes (DEGs) were mapped ont...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6537fcb-d1fe-567a-9185-fa7e4e1c69d8
DOI: 10.21203/rs.3.rs-8417562/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Bioinformatics of Bulk and Single-Cell Transcriptomes Identifies Predictive Molecular Features of Ulcerative Colitis-Associated Colorectal CancerDOI 10.21203/rs.3.rs-8417562/v1Read

Landscape of Cell Heterogeneity and Evolutionary Trajectory in Ulcerative Colitis-associated Colon Cancer Revealed by Single-cell Rna SequencingSemantic proximity Read

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencingSemantic proximity Read

Decoding the mosaic of inflammatory bowel disease: Illuminating insights with single-cell RNA technologySemantic proximity Read

Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.Semantic proximity Read

Establishing and validating a prognostic model for colorectal cancer patients by integrating data from single-cell RNA sequencing and bulk RNA sequencingSemantic proximity Read

Evaluation of colorectal cancer in ulcerative colitis reveals key immune factors during its malignant transformationSemantic proximity Read

Integration of single-cell transcriptome and genetic profiles reveals critical cell types and genes in inflammatory bowel diseaseSemantic proximity Read

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity Read

Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapySemantic proximity Read

Integrated single-cell and bulk RNA-seq for constructing a prognostic risk model of immune-related genes in colorectal cancerSemantic proximity Read

Transcriptomic profiling of lymphocytic colitis highlights distinct diarrhoeal pathomechanismsSemantic proximity Read