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Article

Functional analysis of the C-terminal positive region in an archaeal GH46 family chitosanase.

International journal of biological macromolecules - 1 Jun 2026

Zi Xiangyu, Ye Jia, Xu Qing, Sun Xiaolong, Fu Yongqian, Chen Yao

Abstract excerpt

Archaeal enzymes often possess unique structural features. Here, we identified an archaeal chitosanase from Methanosarcina thermophila, mtCsn46, which contains a charged C-terminal extension. Experimental results showed that the positively charged region (PR) plays a critical role in enzyme function. Molecular dynamics (MD) simulations revealed that PR is positioned above the substrate-binding pocket,...

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PMID: 42107574
DOI: 10.1016/j.ijbiomac.2026.152463

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