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Article

Engineering the conserved and noncatalytic residues of a thermostable β-1,4-endoglucanase to improve specific activity and thermostability.

Scientific reports - 13 Feb 2018

Chen Xiutao, Li Weiguang, Ji Peng, Zhao Yang, Hua Chengyao, Han Chao

Abstract excerpt

Endoglucanases are increasingly applied in agricultural and industrial applications as a key biocatalyst for cellulose biodegradation. However, the low performance in extreme conditions seriously challenges the enzyme's commercial utilization. To obtain endoglucanases with substantially improved activity and thermostability, structure-based rational design was carried out based on the Chaetomium thermophilum...

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Identifiers

PMID: 29440674
DOI: 10.1038/s41598-018-21246-8
PMCID: PMC5811441

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Source receipt: pubmed, retrieved 7 Sept 2026.

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