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Article

The role of active site aromatic residues in substrate degradation by the human chitotriosidase.

Biochimica et biophysica acta - 1 Feb 2016

Eide Kristine Bistrup, Stockinger Linn Wilhelmsen, Lewin Anna Sofia, Tøndervik Anne, Eijsink Vincent G H, Sørlie Morten

Abstract excerpt

Human chitotriosidase (HCHT) is a glycoside hydrolase family 18 chitinase synthesized and secreted in human macrophages thought be an innate part of the human immune system. It consists of a catalytic domain with the (β/α)8 TIM barrel fold having a large area of solvent-exposed aromatic amino acids in the active site and an additional family 14 carbohydrate-binding module. To gain further insight into enzyme...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26621384
DOI: 10.1016/j.bbapap.2015.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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