HLA-B alleles confer susceptibility to sulfasalazine-induced severe cutaneous adverse reactions.

doi:10.1016/j.jaci.2026.04.017

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Article

HLA-B alleles confer susceptibility to sulfasalazine-induced severe cutaneous adverse reactions.

The Journal of allergy and clinical immunology - 1 Sept 2026

Wang Chuang-Wei, Chen Wei-Ti, Chen Chun-Bing, Chu Chia-Yu, Chung-Yee Hui Rosaline, Lu Chun-Wei, Chiu Tsu-Man, Hung Shuen-Iu, Huei Huang Yu, Tassaneeyakul Wichittra, Choon Siew-Eng, Nakkam Nontaya, Sukasem Chonlaphat, Jan Wu Yeong-Jian, Chung Hsin-Yu, Lung Jr-Hau, Chang Jeng-Shou, Lee Yun-Shien, Chang Ya-Ching, Yu Kuang-Hui, Teng Yu-Chuan, Lin Shang-Hung, Lai Kuo-Chu, Hou Hsin-Han, Wu Jennifer, Chi Min-Hui, Lee Hua-En, Yu-Wei Lin Yang, Lin Yu-Jr, Chung Wen-Hung

Abstract excerpt

BACKGROUND: Sulfasalazine is a disease-modifying antirheumatic drug used to treat arthritis and ankylosing spondylitis. However, it may cause life-threatening severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. OBJECTIVE: Genetic predisposition to sulfasalazine-induced SCARs was assessed. METHODS:...

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Topics

Humans
Sulfasalazine
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HLA-B Antigens

Female

Alleles

Male

Adult

Middle Aged

Stevens-Johnson Syndrome

Antirheumatic Agents

Taiwan

Source

Open in PubMed

Identifiers

PMID: 42092593
DOI: 10.1016/j.jaci.2026.04.017

Provenance

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