Analysis of HLA-B Allelic Variation and IFN-γ ELISpot Responses in Patients with Severe Cutaneous Adverse Reactions Associated with Drugs.

doi:10.1016/j.jaip.2018.05.004

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Article

Analysis of HLA-B Allelic Variation and IFN-γ ELISpot Responses in Patients with Severe Cutaneous Adverse Reactions Associated with Drugs.

The journal of allergy and clinical immunology. In practice - 1 Jan 2019

Klaewsongkram Jettanong, Sukasem Chonlaphat, Thantiworasit Pattarawat, Suthumchai Nithikan, Rerknimitr Pawinee, Tuchinda Papapit, Chularojanamontri Leena, Srinoulprasert Yuttana, Rerkpattanapipat Ticha, Chanprapaph Kumutnart, Disphanurat Wareeporn, Chakkavittumrong Panlop, Tovanabutra Napatra, Srisuttiyakorn Chutika

Abstract excerpt

BACKGROUND: The prevention and confirmation of drug-induced severe cutaneous adverse reactions (SCARs) are difficult. OBJECTIVE: To determine the benefit of HLA-B allele prescreening and the measurement of drug-specific IFN-γ-releasing cells in the prevention and identification of the culprit drug in patients with SCARs. METHODS: A total of 160 patients with SCARs were recruited from 6 university hospitals in...

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PMID: 29800753
DOI: 10.1016/j.jaip.2018.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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