Article
Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus.
Clinical pharmacology and therapeutics - 1 May 2018
Wadelius Mia, Eriksson Niclas, Kreutz Reinhold, Bondon-Guitton Emmanuelle, Ibañez Luisa, Carvajal Alfonso, Lucena M Isabel, Sancho Ponce Esther, Molokhia Mariam, Martin Javier, Axelsson Tomas, Kohnke Hugo, Yue Qun-Ying, Magnusson Patrik K E, Bengtsson Mats, Hallberg Pär
Abstract excerpt
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. We performed a genome-wide association study comprising 9,380,034 polymorphisms and 180 HLA alleles in 36 cases of sulfasalazine-induced agranulocytosis and 5,170 population controls. Sulfasalazine-induced agranulocytosis was significantly associated with the HLA region on...
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